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Missy Moreno is at home with her dad, Marcus, when they receive word to come to the rescue of heroes where Missy has to go with her father and be with other Heroics' children.

Missy meets the other children there:

Wheels, who possesses super-strength, but his muscles are too heavy for his skeletal system to support.
Noodles, who can stretch his body.
Ojo, who is mute and communicates through art.
A-Capella, who can telekinetically manipulate objects by singing
Slo-Mo, who is always in slow motion
Face Maker, who can morph his face into anyone
Rewind and Fast Forward, twins who can alter time
Wild Card, who has immense powers but no control over it
Guppy, who has "shark strength" and can shape water into anything she can imagine
The kids watch the battle between the aliens and Heroics on television, ending with the Heroics' capture. Missy realizes that Ojo's drawings tell the future. When a drawing shows aliens breaking into the vault, the kids hatch a plan to escape.

Face Maker tricks the guards into coming into the vault where Guppy subdues them, but not before one of the guards triggers an emergency lockdown. Rewind sends them back in time, Wheels stops the guard from pushing the button, and Noodles steals their security badges. Mrs. Granada spots Missy in the hallway and seals the doors, but A-Capella makes a staircase to the roof, allowing them to escape. Noodles secure a vehicle, and the kids escape.

They land at the home of Missy's grandmother, Anita Moreno, who is the Heroics' trainer and helps the kids master their powers and work as a team. The aliens arrive and Grandma sends the kids through a tunnel that leads to an empty field before she is captured. The kids spot an empty alien craft and use it to reach the Mother ship. Locating a room with a purple pyramid, they see the president and Ms. Granada speaking. They are alien spies, sent to prepare Earth for a "takeover". The kids are placed in a cell. Guppy makes a replica of the key from the children's tears and opens the door. A fight between the kids and the aliens ensues, and Wild Card is caught and taken for questioning while the others seek the pyramid.