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In a post-apocalyptic world, Malorie Hayes informs two young children that they will go down a river in a rowboat. She sternly instructs them not to remove their blindfolds, or they will die.

Five years earlier, a pregnant Malorie is visited by her sister, Jessica. A news broadcast reports unexplained mass suicides spreading across Europe and Asia. After a prenatal checkup, Malorie witnesses a woman smashing her head repeatedly into the hospital window. Others start acting suicidal as well, causing panic and chaos. Afterward, Malorie hurries to leave the scene with Jessica. While steering away from the hospital, Jessica sees something inexplicable that drives her insane and she deliberately crashes her car. She then walks in front of a speeding truck and is killed.

As Malorie flees on foot, a woman invites her into a house for safety. The woman then sees the entity before going into a trance and sitting inside a burning car. A passerby, Tom, picks up Malorie from the street into the house, where six other people – Douglas, Greg, Cheryl, Felix, Charlie, and Lucy – are taking shelter. Charlie says that humanity has been judged, and the appearance of demonic entities is a sign of the end times. He also mentions that those spiritual beings have different names in various cultures, such as Aka Manah, Surgat, Huli Jing, and Púca. Those in the house cover all the windows and blindfold themselves whenever they go out. As a new pregnant survivor, Olympia, arrives, Greg commits suicide after volunteering to test if it is safe to observe them indirectly through surveillance cameras.

Half of the group goes to the grocery store Charlie worked at to restock their dwindling food. They drive there in a car with covered windows using GPS navigation system. Malorie gets three pet birds along with their supplies. She notices the entities' presence agitates the birds. Later, Charlie's coworker attacks the group, attempting to force them to look at the creatures. However, Charlie sacrifices himself to save the others. They make it back to the house. Sometime after, Felix and Lucy steal the car and drive away.